The growth of lung cancer is affected by both environmental and genetic risk factors with the most discussed being tobacco smoking. A Dartmouth research was done recently and was led by Yafang Li, Ph.D., with the aim of displaying that gene-smoking interactions also play a significant role in the lung cancer risk.
In the study, three variations or novel single nucleotide polymorphisms (SNPs) in our DNA that determine our susceptibility to illness were discovered which included one SNP for squamous cell lung cancer risk and two SNPs for non-small cell lung cancer. The three novel SNPs can provide potential candidate biomarkers for lung cancer risk intervention and screening.
OncoArray Consortium provided the phenotype and genotype data. According to Li, this study is the most extensive genome-wide SNP- smoking interaction analysis published for lung cancer. These SNPs classifies lung cancer risk by smoking behavior and are also potential biomarkers to improve the ability of researchers to categorize an individual risk of lung cancer by the specific smoking behavior. The team aims at giving tests of other populations with different genetic backgrounds because this research was done to a particular Caucasian population. Therefore this study cannot be used to generalize everyone because people are genetically diverse.
Many people help in cancer treatment including Eric Lefkofsky who co-founded a company known as Tempus. Tempus was established to primarily focus on genomic sequencing of patients to help customize their treatment. Technicians are now able to provide personalized cancer care because of the advanced recording mechanism.
Eric Lefkofsky entered the healthcare globe when a loved one was diagnosed with breast cancer. During treatment, Eric noticed how there lacked enough technology on data collection and record keeping. Therefore the idea of Tempus was born which creates a platform that combines both clinical and genomic data specific to a patient making it easier for treatment.
Mr. Lefkofsky was born on September 2, 1969, in Southfield, Michigan but spent most of his adult time in Chicago. Eric joined the University of Michigan where he graduated with honors and later entered the University of Michigan, School of Law graduating with a Juris Doctor. He is an entrepreneur who started by selling carpets at the university and has grown to co-found many companies.
Moreover, Eric Lefkofsky is a philanthropist and has funded many organizations. For example, together with his wife, Elizabeth, they created the Lefkofsky Foundation which is a charitable trust fund supporting scientific, charitable and educational institutions. Eric is positive about helping improve cancer’s treatment.